Guanhua Lai, MD, PhD
Hematopathology & Transfusion Medicine
Associate Professor of Pathology
Department: Pathology
Phone: (804) 828-7828
Fax: (804) 828-2812
Email: Guanhua.Lai@vcuhealth.org
Dr. Guanhua Lai, MD, PhD, graduated from Suzhou Medical College and earned a PhD in Molecular Biology from Shanghai Second Medical University. He completed his residency in Anatomic and Clinical Pathology and received Fellowship training in Hematopathology at Virginia Commonwealth University Health System.
Dr. Lai has received post-doctoral fellowship training at Virginia Commonwealth University in the laboratory of Dr. Alphonse Sirica. His current research interest is about cholestatic liver injury and the pathogenesis, diagnosis, and treatment of hematopoietic neoplasms.
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Dr. Guanhua Lai abbreviated CV
Education
Postgraduate Medical Training
Fellowship - Hematopathology, Department of Pathology
Virginia Commonwealth University Health System, Richmond, Virginia
Residency - AP/CP training program, Department of Pathology
Virginia Commonwealth University Health System, Richmond, Virginia
Medical Education
Suzhou Medical College Suzhou, Jiangsu 215007, P. R. China
Graduate Education
PhD of Molecular Biology - Shanghai Second Medical University, Shanghai 200025, P. R. China
MS - Suzhou Medical College Suzhou, Jiangsu 215007, P. R. China
Licenses & Certifications
Medical Licenses (Current)
Board of Medicine, Commonwealth of Virginia
Board Certifications
Diplomate, American Board of Pathology, combined Anatomic and Clinical Pathology
Diplomate, American Board of Pathology, Hematology
Recent Grants & Funding
2024-2028 NIH 1R01DK139587-01, 09/2024–07/2028, Total Award Amount (including Indirect Costs): $561,785, Circular RNAs in Cholestatic Liver Diseases, Co-PI, 2.4% effort
2023-2028 NIH/NIAAA 5R01AA030180-02, 07/01/2023-04/30/2028, Total Award Amount (including Indirect Costs): $1,046,124 , Sphingolipids in alcoholic liver disease, Co-PI, 2.4% effort
Selected Publications
Mihori M, Bryson A, Doern C, Farhat F, Lai G, Mochel M, Morales M, Smallfield M, Tchoukina I, Vissichelli N. Case Report: Donor-derived Chagas Disease post-heart transplant after false-negative donor Trypanosoma cruzi testing, 2025, Transplantation Direct, 2025 Oct 3;11(11):e1864 DOI: 10.1097
Rothschild SC, Lai G, Tombes RM, and Clements WK. 2023 Constitutively active CaMKII Drives B lineage acute lymphoblastic leukemia/lymphoma in tp53 mutant zebrafish PLOS Genetics Dec 20;19(12):e1011102, PMID: 38117861
Gillam J, Catic A, Paulraj P, Dalton J, Lai G, Jackson-Cook C, Turner S, Ferreira-Gonzalez A, and Barrie E 2022 Acute Megakaryoblastic Leukemia with Trisomy 3 andCBFA2T3-GLIS2, A Case Report. Genes, Chromosomes and Cancer Aug;61(8):491496, PMID: 35294081
Liaquat S, Lai G, Patel S, and Jayakumar R 2021 Rare case of CD3- T cell larger granular lymphocytic leukemia; a diagnostic pitfall Arch Pathol Lab Med (2021 Sept) 145 (9): e79
Y Wang, YL Tai, D Zhao, Y Zhang, J Yan, G Kakiyama, X Wang, EC. Gurley, J Liu, J Liu, J Liu, G Lai, PB. Hylemon, WM. Pandak, W Chen, and H Zhou 2021 Berberine prevents disease progression of nonalcoholic teatohepatitis through multiple target Cells Jan 21; 10(2):210, PubMed PMID: 33494295
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