Guanhua Lai, MD, PhD
Hematopathology & Transfusion Medicine
Associate Professor of Pathology
Department: Pathology
Phone: (804) 828-7828
Fax: (804) 828-2812
Email: Guanhua.Lai@vcuhealth.org
Dr. Guanhua Lai, MD, PhD, graduated from Suzhou Medical College and earned a PhD in Molecular Biology from Shanghai Second Medical University. He completed his residency in Anatomic and Clinical Pathology and received Fellowship training in Hematopathology at Virginia Commonwealth University Health System.
Dr. Lai has received post-doctoral fellowship training at Virginia Commonwealth University in the laboratory of Dr. Alphonse Sirica. His current research interest is about cholestatic liver injury and the pathogenesis, diagnosis, and treatment of hematopoietic neoplasms.
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Dr. Guanhua Lai abbreviated CV
Education
Postgraduate Medical Training
Fellowship - Hematopathology Department of Pathology
Virginia Commonwealth University Health System Richmond, Virginia
Residency - AP/CP training program Department of Pathology
Virginia Commonwealth University Health System Richmond, Virginia
Medical Education
Suzhou Medical College Suzhou,
Jiangsu 215007
P.R. China
Graduate Education
PhD of Molecular Biology
Shanghai Second Medical University
Shanghai 200025
P.R. China
MS
Suzhou Medical College Suzhou,
Jiangsu 215007
P.R. China
Licenses & Certifications
Medical Licenses (Current)
Board of Medicine, Commonwealth of Virginia
Board Certifications
Diplomate, American Board of Pathology, combined Anatomic and Clinical Pathology
Diplomate, American Board of Pathology, Hematology
Recent Grants and Funding
2023-2028 NIH/NIAAA R01AA030180, 07/01/2023-04/30/2028, annual direct cost: $336,916, Sphingolipids in alcoholic liver disease, Co-PI, 2% effort
2018-2024 National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS, 2R56DK115377-05A1, 07/25/2018-08/31/2024, LncRNA H19 in Cholestatic Liver Diseases, $405,528, Co-PI, 2% effort
Selected Publications
Rothschild SC, Lai G, Tombes RM, and Clements WK. 2023 Constitutively active CaMKII Drives B lineage acute lymphoblastic leukemia/lymphoma in tp53 mutant zebrafish PLOS Genetics Dec 20;19(12):e1011102, PMID: 38117861
Gillam J, Catic A, Paulraj P, Dalton J, Lai G, Jackson-Cook C, Turner S, Ferreira-Gonzalez A, and Barrie E 2022 Acute Megakaryoblastic Leukemia with Trisomy 3 and CBFA2T3-GLIS2, A Case Report. Genes, Chromosomes and Cancer Aug;61(8):491-496, PMID: 35294081
Liaquat S, Lai G, Patel S, and Jayakumar R 2021 Rare case of CD3- T cell larger granular lymphocytic leukemia; a diagnostic pitfall Arch Pathol Lab Med (2021 Sept) 145 (9): e79.
Y Wang, YL Tai, D Zhao, Y Zhang, J Yan, G Kakiyama, X Wang, EC. Gurley, J Liu, J Liu, J Liu, G Lai, PB. Hylemon, WM. Pandak, W Chen, and H Zhou 2021 Berberine prevents disease progression of nonalcoholic teatohepatitis through multiple target Cells Jan 21; 10(2):210, PubMed PMID: 33494295
Godbey EA, Dalton JB, Lai G, Sanford KW, Roseff SD. First reported case of leukocytapheresis in plasma cell leukemia Transfusion. 2020 Jan; 60(1):11-12, PMID: 31682280
Alder L, Graupner S, Lai G, and Yazbeck V. 2019 Case of a CD3 negative hepatosplenic T-cell lymphoma: diagnostic and therapeutic challenges Case Reports in Hematology Volume 2019 June 27; 2019:5315086, PMID: 31346479
Liu R, Li X, Zhu W, Wang Y, Zhao D, Wang X, Gurley EC, Liang G, Chen W, Lai G, Pandak WM, Robert Lippman H, Bajaj JS, Hylemon PB, Zhou H. 2019 Cholangiocyte-derived exosomal LncRNA H19 promotes hepatic stellate cell activation and cholestatic liver fibrosis Hepatology. Oct;70(4):1317-1335 PMID: 30985008
Kwong EK, Liu R, Zhao D, Li X, Zhu W, Wang X, Gurley EC, Lai G, Liu J, Hylemon PB, Zhou H. 2019 The role of sphingosine kinase 2 in alcoholic liver disease Dig Liver Dis. Aug;51(8):1154-1163. PMID: 31003959
Li X, Liu R, Huang Z, Gurley EC, Wang X, Huang J, He H, Yang H, Lai G, Zhang L, Bajaj JS, White W, Pandak WM, Hylemon PB, and Zhou H 2018 Cholangiocyte-derived exosomal long noncoding RNA H19 promotes cholestatic liver injury in mouse and human Hepatology Aug;68(2):599-615 PMID: 29425397
Liu R, Li X, Huang Z, Zhao D, Ganesh BS, Lai G, Pandak WM, Hylemon PB, Bajaj JS, Sanyal AJ, Zhou H. 2018 C/EBP homologous protein-induced loss of intestinal epithelial stemness contributes to bile duct ligation-induced cholestatic liver injury in mice Hepatology. Apr;67(4):1441-1457 PMID: 28926118
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