Lorin Bachmann, PhD, DABCC

Clinical Chemistry

Lorin Bachmann, PhD, DABCCProfessor of Pathology; Co-Director of Clinical Chemistry; Co-Director of Point of Care Testing; Director of the Blood Gas Laboratory; Director of the New Kent Emergency Department Laboratory; Associate Director, Pathology Information Systems; Technical Director, Clinical Pathology Research Services

Department: Pathology

Phone: (804) 828-6407

Email: Lorin.Bachmann@vcuhealth.org

Lorin Bachmann, PhD, DABCC, joined the VCU Department of Pathology in 2007. In addition to VCU service responsibilities listed above, Dr. Bachmann also serves as the Technical Director for the VCUH Anesthesiology Laboratory, Technical Director for the VCUH Clinical Pathology Research Services, and Laboratory Director for multiple VCUHS outreach laboratories.

Dr. Bachmann received a PhD in Molecular Medicine from the University of Virginia, followed by a fellowship in clinical chemistry and proteomics research at the University of Virginia. She is certified by the American Board of Clinical Chemistry. Dr. Bachmann is a member of the Clinical Laboratory and Standards Institute (CLSI) Expert Panel on Clinical Chemistry and Toxicology, the CLSI Board of Directors, the College of American Pathologists (CAP) Standards Committee, and the National Kidney Disease Education Program (NKDEP)/International Federation of Clinical Chemistry Laboratory (IFCC) Joint Lab Working Group. Dr. Bachmann’s research interests include evaluation and validation of new clinical laboratory assays, clinical laboratory analyzer design and standardization of laboratory testing. Dr. Bachmann has received numerous awards for her contributions to professional societies, education, and research.

Clinical Specialties: Clinical Chemistry and Laboratory Medicine, Point-of-Care Testing, Clinical and Translational Research


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Dr. Lorin Bachmann abbreviated CV

Education

2007            Clinical Chemistry and Laboratory Medicine Fellow University of Virginia, Charlottesville, VA

2005            PhD, Molecular Medicine, University of Virginia, Charlottesville, VA

2005            Biotechnology Training Program Fellow, University of Virginia, Charlottesville, VA

1996            BS, Biology/Medical Technology, Virginia Tech, Blacksburg, VA

Licenses & Certifications

2008            Diplomate of the American Board of Clinical Chemistry (DABCC)

1996            American Society of Clinical Pathologists (ASCP), Medical Technologist (MT)

Selected Awards & Honors

2025            Certificate of Appreciation: College of American Pathology (CAP). Awarded for contributions to the CAP Accuracy Based Programs Committee

2022            CLSI Service Award: Clinical and Laboratory Standards Institute (CLSI). Awarded for contributions to CLSI C62 guidelines document, Liquid Chromatography Mass Spectrometry Methods

2019            Plenary Lecture Award: Clinical and Pharmaceutical Solutions through Analysis (CPSA). Awarded for contributions in clinical analysis across disciplines.

2017            Outstanding Speaker Award: American Association for Clinical Chemistry (AACC)

2017            Excellence in Education Award: American Association for Clinical Chemistry

2016            CLSI Service Award: Clinical and Laboratory Standards Institute (CLSI). Awarded for contributions to CLSI C57 guidelines document, Mass Spectrometry for Androgen and Estrogen in Serum

Recent Grants and Funding

 Former Grants

Evaluation of Use of Single Donor Urine Specimens for Commutability Assessment of Reference Materials for Development of Reference Measurement Systems for Urine Albumin.
Sponsor: National Institutes of Standards and Technology (NIST).
Role: Principal Investigator 7/17/2023-7/16/2024

 Alinity i Transplant Assay Clinical Evaluation Protocol.
Sponsor: Abbott Laboratories.
Role: Principal Investigator 5/16/2019-2021

 Alinity i STAT hsTnI Design Validation.
Sponsor: Abbott Laboratories.
Role: Principal Investigator 1/1/19-12/8/20

Professional Service (outside)

2025 - present       Member, Document Development Committee, Clinical and Laboratory Standards Institute (CLSI), CLSI QMS30, Good Clinical Practice (GCP) for Participation in Clinical Studies and Trials.  

2025 - present       Scientific Session Planning Committee Member, 2026 Annual Meeting Organizing Committee, Association for Diagnostics and Laboratory Medicine (ADLM).

2024 - present       Member, College of American Pathology Standards Committee.

2023 - present       Member, Board of Directors, Clinical Laboratory and Standards Institute (CLSI).

2023 - present       Member, Clinical Laboratory and Standards Institute (CLSI) Expert Panel on Clinical Chemistry and Toxicology.

2022 - 2025            Member, Document Development Committee, Clinical and Laboratory Standards Institute (CLSI), CLSI EP21/EP46, Total Analytical Error.

2021 - present       Member, Document Development Committee, Clinical and Laboratory Standards Institute (CLSI), CLSI EP44, a revision of CLSI EP28-A3c, Verifying Reference Intervals in a Medical Laboratory.

2019 - present       Member, National Kidney Disease Education Program/International Federation of Clinical Chemistry Laboratory Joint Working Group (NKDEP/IFCC LWG) for Standardization of Urine Albumin.

2019 - present       Member, College of American Pathology Accuracy Based Programs Committee.

Recent Invited Presentations

2024 Embracing New Quality Specifications: Adjusting Lab Practices - CLIA 2024 and Beyond. Evaluating the Impact of an Out-of-Control Event. Association for Diagnostics and Laboratory Medicine (ADLM) Annual Meeting, Chicago, IL.

2023 LC-MSMS 101:  Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory (4-day workshop). Virtual Short Course

2022 Albumin Harmonization: Impact on Serum, Urine, and Body Fluid Interpretation. American Association for Clinical Chemistry (AACC) Annual Scientific Meeting, Chicago, IL.

2022 CLSI EP26, User Evaluation of Acceptability of a Reagent Lot Change, Clinical and Laboratory Standards Institute, Internationally broadcast webinar

2022 Perspectives on Quality Control Challenges in the Clinical Laboratory. American Association for Clinical Chemistry (AACC) Annual Scientific Meeting, Chicago, IL.

2021 Best Practices to Recover from an Out-of-Control Event, Bio-Rad Quality Control Conference, National Webinar

Selected Publications

Peer Reviewed Papers

Campbell MR, Astles JR, Bachmann LM, Brun M, Bryksin J, Erdosy M, Galior K, Holland M, Jennings B, Kondratovich M, Ladwig P, Love S, Antonio Pereira PA, Yundt-Pacheco J. Evaluation of Total Analytical Error for Quantitative Medical Laboratory Procedures. 3rd Ed. CLSI Guideline EP21. Clinical and Laboratory Standards Institute, USA; 2025.

Miller WG, Beasley-Green A, Bachmann LM, Budd J, Tan HT, Teo TL, Liu Q, Phinney KW, Shiba S, Seegmiller J. Extent of equivalence of results for urine albumin among three candidate mass spectrometry reference measurement procedures. Clin Chem, 2024; 70(11):1375-1382.

Seegmiller JC, Bachmann LM. Urine Albumin Measurements in Clinical Diagnostics [Review]. Clin Chem. 2024; 70(2):382-391.

Williams GW, Downs JW, Wolf CE, Cumpston KL, Tobarran N, Wills BK, Bachmann LM. Evaluation of Strontium Interference in Calcium Measurement Procedures and Content in Supplements as Measured by ICP-MS. JALM. 2023;8(2):307-318.

DeVore K, Holland M, Bachmann LM, Chromczak JG, Crepet F, Duncan J, Fennell S, Fertey J, Meng QH, Pierson-Perry JF, Pistorino M, Renley R, Simmons VL, Tusneem NA, Varlan AR, Xiong K. CLSI. Evaluation of Stability of In Vitro Medical Laboratory Test Reagents. 2nd ed. CLSI Guideline EP25. Clinical and Laboratory Standards Institute; 2023.

Johansen JV, Bachmann LM, Babic N, D’Agostino PM, Danilenko U, Durham AP, Goldford MD, Long IS, Miller WG, Person NB, Standord JE, Vandepoele N, Varlan AR. Clinical and Laboratory Standards Institute (CLSI).User Evaluation of Acceptability of a Reagent Lot Change, 2nd Edition. CLSI guideline EP26. Clinical and Laboratory Standards Institute, USA, 2022.

Clarke W, Molinaro RJ, Bachmann LM, Botelho JC, Cao Z, French D, Garg S, Gawoski JM, Grant RP, Hoofnagle AN, Iyer Bagyalakshmi, Kulasingam V, Mason DS, Rappold B, Tacker DH, Truscott SM, Yu Chunli, Zhu Yusheng. Clinical and Laboratory Standards Institute (CLSI). Liquid Chromatography-Mass Spectrometry Methods, 2nd Edition. CLSI guideline C62. Clinical and Laboratory Standards Institute, USA, 2022.

Bystrom C, Grant RP, Bachmann LM, DeMarco M, Holmes DT, Hoofnagle AN, Intelmann D, Jeffery D, Kushnir MM, Ladwig P, Lowenthal MS, Master SR, Shuford CM, Thomas S, Whiteaker J. Clinical and Laboratory Standards Institute (CLSI). Quantitative Measurement of Proteins and Peptides by Mass Spectrometry. 1st ed. CLSI guideline C64. Clinical and Laboratory Standards Institute; 2021.

Book Chapters and Monographs
Bachmann LM, Miller GW. Principles of spectrophotometry and related photometric measurements. In: Clarke W, Dufour RD, eds. Contemporary Practice in Clinical Chemistry. Fourth edition. Washington D.C.: AACC Press. 2020:119-133.

Cook JC, Bachmann LM, French D. Steroid Hormones. In: Nair H, Clarke W, eds. Mass Spectrometry for the Clinical Laboratory. First edition. Cambridge: Elsevier Inc, 2017:205-226.


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