Department of Pathology Research Division Success Stories
The human intermediate prolactin receptor is a mammary proto-oncogene. Jacqueline M Grible, Patricija Zot, Amy L Olex, Shannon E Hedrick, J Chuck Harrell, Alicia E Woock, Michael O Idowu, Charles V Clevenger
NPJ Breast Cancer. 2021 Mar 26;7(1):37. doi: 10.1038/s41523-021-00243-7.PMID: 33772010
Senthil Radhakrishnan was awarded a grant from the American Cancer Society. "Understanding and Targeting Nrf1 Pathway in Triple-negative Breast Cancer"
$165,000 direct/year for 4 years Co-I: Harrell, Koblinski, Gewirtz, McClay
Justin Craig completed the requirements for a Degree of Doctor of Philosophy in the Clinical and Translational Science Program
Alicia Woock completed the requirements for a Degree of Doctor of Philosophy in the Clinical and Translational Science Program
A publication from Justin Craig, Tia Turner, Chuck Harrell, and Charles Clevenger is the current featured article by the Endocrine Society. https://academic.oup.com/endo
A publication from Tia Turner, Mohammad Alzubi, and Chuck Harrell is included in Scientific Reports Top 100 downloaded cancer papers for 2020, at 25th. https://www.nature.com/collections/aijhgffdjh
Regulatory T Cells Support Breast Cancer Progression by Opposing IFN-γ-Dependent Functional Reprogramming of Myeloid Cells.
Clark NM, Martinez LM, Murdock S, deLigio JT, Olex AL, Effi C, Dozmorov MG, Bos PD.
Cell Rep. 2020 Dec 8;33(10):108482. doi: 10.1016/j.celrep.2020.108482.
Local Targeting of Lung-Tumor-Associated Macrophages with Pulmonary Delivery of a CSF-1R Inhibitor for the Treatment of Breast Cancer Lung Metastases.
Alhudaithi SS, Almuqbil RM, Zhang H, Bielski ER, Du W, Sunbul FS, Bos PD, da Rocha SRP.
Mol Pharm. 2020 Dec 7;17(12):4691-4703. doi: 10.1021/acs.molpharmaceut.0c00983. Epub 2020 Nov 10.
Harrell and Clevenger Labs
Breast cancer liver metastasis: current and future treatment approaches.
Rashid NS, Grible JM, Clevenger CV, Harrell JC.
Clin Exp Metastasis. 2021 Mar 6. doi: 10.1007/s10585-021-10080-4. Online ahead of print.
Prolactin Drives a Dynamic STAT5A/HDAC6/HMGN2 Cis-Regulatory Landscape Exploitable in ER+ Breast Cancer.
Craig JM, Turner TH, Harrell JC, Clevenger CV.
Endocrinology. 2021 Feb 16:bqab036. doi: 10.1210/endocr/bqab036. Online ahead of print.
Harrell and Bos Labs
Unexpected PD-L1 immune evasion mechanism in TNBC, ovarian, and other solid tumors by DR5 agonist antibodies.
Mondal T, Shivange GN, Tihagam RG, Lyerly E, Battista M, Talwar D, Mosavian R, Urbanek K, Rashid NS, Harrell JC, Bos PD, Stelow EB, Stack MS, Bhatnagar S, Tushir-Singh J.
EMBO Mol Med. 2021 Mar 5;13(3):e12716. doi: 10.15252/emmm.202012716. Epub 2021 Feb 15.
MYCN-amplified neuroblastoma is addicted to iron and vulnerable to inhibition of the system Xc-/glutathione axis.
Floros KV, Cai J, Jacob S, Kurupi R, Fairchild CK, Shende M, Coon CM, Powell KM, Belvin BR, Hu B, Puchalapalli M, Ramamoorthy S, Swift K, Lewis JP, Dozmorov MG, Glod J, Koblinski JE, Boikos SA, Faber AC.
Cancer Res. 2021 Jan 22:canres.1641.2020. doi: 10.1158/0008-5472.CAN-20-1641. Online ahead of print.
Conformational Modulation of Iduronic Acid-Containing Sulfated Glycosaminoglycans by a Polynuclear Platinum Compound and Implications for Development of Antimetastatic Platinum Drugs.
Gorle AK, Haselhorst T, Katner SJ, Everest-Dass AV, Hampton JD, Peterson EJ, Koblinski JE, Katsuta E, Takabe K, von Itzstein M, Berners-Price SJ, Farrell NP.
Angew Chem Int Ed Engl. 2021 Feb 8;60(6):3283-3289. doi: 10.1002/anie.202013749. Epub 2020 Dec 23.
Hsp70 acts as a fine-switch that controls E3 ligase CHIP-mediated TAp63 and ΔNp63 ubiquitination and degradation.
Wu HH, Wang B, Armstrong SR, Abuetabh Y, Leng S, Roa WHY, Atfi A, Marchese A, Wilson B, Sergi C, Flores ER, Eisenstat DD, Leng RP.
Nucleic Acids Res. 2021 Feb 22:gkab081. doi: 10.1093/nar/gkab081. Online ahead of print.
Human Papillomavirus 16 (HPV16) E2 Repression of TWIST1 Transcription Is a Potential Mediator of HPV16 Cancer Outcomes.
Fontan CT, Das D, Bristol ML, James CD, Wang X, Lohner H, Atfi A, Morgan IM.
Loss of Jag1 cooperates with oncogenic Kras to induce pancreatic cystic neoplasms.
Chung WC, Challagundla L, Zhou Y, Li M, Atfi A, Xu K.
Life Sci Alliance. 2020 Dec 2;4(2):e201900503. doi: 10.26508/lsa.201900503. Print 2021 Feb.
Youngman Oh, (pictured) School of Medicine VETAR grant. “Development of a novel targeted therapy for age-related macular degeneration”. A MultiPI application with Dr. Qinggu Xu in Pharmaceutics to investigate therapeutic potential of IGFBP-3R mAb for dry AMD using a sodium iodate AMD mouse model.
Michael Idowu and Chuck Harrell are Co-Investigators on a R01 from the NCI, with PI David Gewirtz (Pharmacology): A sequential therapeutic strategy of senescence induction and senolytics for elimination of surviving residual breast tumor cells. $3.3M
Chuck Harrell served on the NIH MCT2 study section March 3-5.
Autophagy-Dependent Sensitization of Triple-Negative Breast Cancer Models to Topoisomerase II Poisons by Inhibition of The Nucleosome Remodeling Factor. Tyutyunyk-Massey L, Sun Y, Dao N, Ngo H, Dammalapati M, Vaidyanathan A, Singh M, Haqqani S, Haueis J, Finnegan R, Deng X, Kirberger SE, Bos PD, Bandyopadhyay D, Pomerantz WCK, Pommier Y, Gewirtz DA, Landry JW. Mol Cancer Res. 2021 Apr 2. doi: 10.1158/1541-7786.MCR-20-0743. Online ahead of print. PMID: 33811160
Cancer-Mediated Muscle Cachexia: Etiology and Clinical Management. Siff T, Parajuli P, Razzaque MS, Atfi A. Trends Endocrinol Metab. 2021 Apr 19:S1043-2760(21)00068-0. doi: 0.1016/j.tem.2021.03.007. Online ahead of print. PMID: 33888422
Chromatin conformation capture (Hi-C) sequencing of patient-derived xenografts: analysis guidelines.
Dozmorov MG, Tyc KM, Sheffield NC, Boyd DC, Olex AL, Reed J, Harrell JC.
Gigascience. 2021 Apr 21;10(4):giab022. doi: 10.1093/gigascience/giab022.
The pharmacy professor and his team are pursuing a treatment that has the potential to "improve and save the lives of millions of people.”
Virginia Commonwealth University will require students taking classes this fall to be vaccinated against COVID-19, university leaders announced Monday.
From slow streets to parklets, quick retrofits of public (and sometimes private) space rapidly expanded in response to COVID-19. While some changes are temporary, others could become permanent.
A leader at VCU for nearly 30 years, Barker spent his life serving others in education, health care and the military, bringing people together to improve the lives of students and patients.
David Cifu’s work in the field includes leading two federally funded projects to address the long-term effects of mild traumatic brain injury in military service personnel and veterans.
Research shows that those with a history of adverse childhood experiences were more likely to bear a heavier burden during the pandemic’s initial surge.
Compiling and analyzing state data plays a major role in testing and the vaccination process.
Why did the rules change so suddenly? Is the change really a good idea? And what about all the exceptions? VCU Health infectious disease expert Michael Stevens weighs in on the new federal guidance.