Lorin Bachmann, PhD, DABCC
Clinical Chemistry
Department: Pathology
Phone: (804) 828-6407
Email: Lorin.Bachmann@vcuhealth.org
Professor of Pathology;
Co-Director of Clinical Chemistry;
Co-Director of Point of Care Testing;
Director of the New Kent Emergency Department
Lorin Bachmann, PhD, DABCC, joined the VCU Department of Pathology in 2007. In addition to VCU service responsibilities listed above, Dr. Bachmann also serves as the Technical Director for the VCUH Anesthesiology Laboratory, Technical Director for the VCUH Clinical Pathology Research Services, and Laboratory Director for multiple VCUHS outreach laboratories.
Dr. Bachmann received a PhD in Molecular Medicine from the University of Virginia, followed by a fellowship in clinical chemistry and proteomics research at the University of Virginia. She is certified by the American Board of Clinical Chemistry. Dr. Bachmann is a member of the Clinical Laboratory and Standards Institute (CLSI) Expert Panel on Clinical Chemistry and Toxicology, the CLSI Board of Directors, the College of American Pathologists (CAP) Accuracy Based Programs Committee, and the National Kidney Disease Education Program (NKDEP)/International Federation of Clinical Chemistry Laboratory (IFCC) Joint Lab Working Group. Dr. Bachmann’s research interests include evaluation and validation of new clinical laboratory assays, clinical laboratory analyzer design, development of mass spectrometry-based assays for the clinical laboratory, and standardization of laboratory testing. She serves as principal investigator for government and industry-sponsored studies. Dr. Bachmann has received numerous awards for her contributions to professional societies, education, and research.
Clinical Specialties: Clinical Chemistry and Laboratory Medicine, Point-of-Care Testing, Clinical and Translational Research
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Dr. Bachmann's abbreviated CV
Education
1996 BS, Biology/Medical Technology, Virginia Tech, Blacksburg, VA
2005 PhD, Molecular Medicine, University of Virginia, Charlottesville, VA
2005 Biotechnology Training Program Fellow, University of Virginia, Charlottesville, VA
2007 Clinical Chemistry and Laboratory Medicine Fellow University of Virginia, Charlottesville, VA
Licenses & Certifications
1996 American Society of Clinical Pathologists (ASCP), Medical Technologist (MT)
2008 Diplomate of the American Board of Clinical Chemistry (DABCC)
Selected Awards & Honors
2022 CLSI Service Award: Clinical and Laboratory Standards Institute (CLSI). Awarded for contributions to CLSI C62 guidelines document, Liquid Chromatography Mass Spectrometry Methods.
2019 Plenary Lecture Award: Clinical and Pharmaceutical Solutions through Analysis (CPSA). Awarded for contributions in clinical analysis across disciplines.
2017 Outstanding Speaker Award: American Association for Clinical Chemistry (AACC).
2017 Excellence in Education Award: American Association for Clinical Chemistry.
2016 CLSI Service Award: Clinical and Laboratory Standards Institute (CLSI). Awarded for contributions to CLSI C57 guidelines document, Mass Spectrometry for Androgen and Estrogen in Serum.
Recent Grants and Funding
Currently active
Evaluation of Use of Single Donor Urine Specimens for Commutability Assessment of Reference Materials for Development of Reference Measurement Systems for Urine Albumin.
Sponsor: National Institutes of Standards and Technology (NIST).
Role: Principal Investigator 7/17/2023-7/16/2024
Alinity i Transplant Assay Clinical Evaluation Protocol.
Sponsor: Abbott Laboratories.
Role: Principal Investigator 5/16/2019-2021
Alinity i STAT hsTnI Design Validation.
Sponsor: Abbott Laboratories.
Role: Principal Investigator 1/1/19-12/8/20
Evaluation of Harmonization of Urine Albumin Measurement.
Sponsor: National Kidney Disease Education Program (NKDEP)/National Institutes of Diabetes and Kidney Disease (NIDDK)
Role: Principal Investigator 5/1/2010-4/3/2012
Professional Service (outside)
2023-present Member, Board of Directors, Clinical Laboratory and Standards Institute (CLSI)
2023-present Member, Clinical Laboratory and Standards Institute (CLSI) Expert Panel on Clinical Chemistry and Toxicology
2022-present Member, Document Development Committee, Clinical and Laboratory Standards Institute (CLSI), CLSI EP21/EP46, Total Analytical Error
2021-present Member, Document Development Committee, Clinical and Laboratory Standards Institute (CLSI), CLSI EP44, a revision of CLSI EP28-A3c, Verifying Reference Intervals in a Medical Laboratory
2019-present Member, National Kidney Disease Education Program/International Federation of Clinical Chemistry Laboratory Joint Working Group (NKDEP/IFCC LWG) for Standardization of Urine Albumin
2019-present Member, College of American Pathology Accuracy Based Programs Committee
Recent Invited Presentations
LC-MSMS 101: Getting Started with Quantitative LC-MS/MS in the Diagnostic Laboratory (4-day workshop). Virtual Short Course, 2023.
Albumin Harmonization: Impact on Serum, Urine, and Body Fluid Interpretation. American Association for Clinical Chemistry (AACC) Annual Scientific Meeting, Chicago, IL, 2022.
CLSI EP26, User Evaluation of Acceptability of a Reagent Lot Change, Clinical and Laboratory Standards Institute, Internationally broadcast webinar 2022.
Perspectives on Quality Control Challenges in the Clinical Laboratory. American Association for Clinical Chemistry (AACC) Annual Scientific Meeting, Chicago, IL, 2022.
Best Practices to Recover from an Out-of-Control Event, Bio-Rad Quality Control Conference, National Webinar. 2021.
Plenary Session: The Impact of Bioanalytical Decision Making on Patient Care.
Clinical and Pharmaceutical Solutions through Analysis (CPSA) Annual meeting, PA.
Measurement of 25-OH Vitamin D using a fully integrated, automated sample preparation system for LC-MS/MS in the routine clinical laboratory. 6th Shimadzu International Collaborative Laboratory Forum, 2018, Fukuoka, Japan.
Evaluation of the Shimadzu CLAM 2000 LCMS 8050 integrated system. Shimadzu Headquarters Meeting, 2018, Kyoto, Japan.
Quality Assurance - The Path to Peace of Mind: Design a Customized and Effective Quality Assurance Program for Your Laboratory, Mass Spectrometry Applications to the Clinical Laboratory (MSACL) annual meeting, 2018, Palm Springs, CA.
Standardization of Urine Albumin Assays, IFCC WorldLab Annual Meeting, Oct 2017, Durban, South Africa.
Selected Publications
Peer Reviewed Papers
Seegmiller JC, Bachmann LM. Urine Albumin Measurements in Clinical Diagnostics [Review]. Clin Chem. Accepted for Publication.
Williams GW, Downs JW, Wolf CE, Cumpston KL, Tobarran N, Wills BK, Bachmann LM. Evaluation of Strontium Interference in Calcium Measurement Procedures and Content in Supplements as Measured by ICP-MS. JALM. 2023;8(2):307-318.
DeVore K, Holland M, Bachmann LM, Chromczak JG, Crepet F, Duncan J, Fennell S, Fertey J, Meng QH, Pierson-Perry JF, Pistorino M, Renley R, Simmons VL, Tusneem NA, Varlan AR, Xiong K. CLSI. Evaluation of Stability of In Vitro Medical Laboratory Test Reagents. 2nd ed. CLSI Guideline EP25. Clinical and Laboratory Standards Institute; 2023.
Johansen JV, Bachmann LM, Babic N, D’Agostino PM, Danilenko U, Durham AP, Goldford MD, Long IS, Miller WG, Person NB, Standord JE, Vandepoele N, Varlan AR. Clinical and Laboratory Standards Institute (CLSI).User Evaluation of Acceptability of a Reagent Lot Change, 2nd Edition. CLSI guideline EP26. Clinical and Laboratory Standards Institute, USA, 2022.
Clarke W, Molinaro RJ, Bachmann LM, Botelho JC, Cao Z, French D, Garg S, Gawoski JM, Grant RP, Hoofnagle AN, Iyer Bagyalakshmi, Kulasingam V, Mason DS, Rappold B, Tacker DH, Truscott SM, Yu Chunli, Zhu Yusheng. Clinical and Laboratory Standards Institute (CLSI). Liquid Chromatography-Mass Spectrometry Methods, 2nd Edition. CLSI guideline C62. Clinical and Laboratory Standards Institute, USA, 2022.
Bystrom C, Grant RP, Bachmann LM, DeMarco M, Holmes DT, Hoofnagle AN, Intelmann D, Jeffery D, Kushnir MM, Ladwig P, Lowenthal MS, Master SR, Shuford CM, Thomas S, Whiteaker J. Clinical and Laboratory Standards Institute (CLSI). Quantitative Measurement of Proteins and Peptides by Mass Spectrometry. 1st ed. CLSI guideline C64. Clinical and Laboratory Standards Institute; 2021.
Bachmann LM, Yu M, Boyd JC, Bruns DE, Miller WG. State of Harmonization of 24 Serum Albumin Measurement Procedures and Implications for Medical Decisions. Clinical Chemistry, 2017; 63(3): 770-779.
Miller GM, Seegmiller JC, Lieske JC, Narva AS, Bachmann LM. Status of Standardization of Urine Albumin Measurement Procedures. JALM 2017; 2(3):423-429.
Bachmann LM, Nilsson G, Bruns DE, McQueen MJ, Lieske JC, Zakowski JJ, Miller WG. State of the Art for Measurement of Urine Albumin: Comparison of Routine Measurement Procedures to Isotope Dilution Tandem Mass Spectrometry. Clin Chem 2014; 60:471-480. Editorial: Scott MG, Coyne DW. Should We Sweat the Small (Micro) Things? Clin Chem 2014; 60:435-437.
Oliveira MJ, van Deventer HE, Bachmann LM, Warnick GR, Nakajima K, Nakamura M, Sakurabayashi I, Kimberly MM, Shamburek RD, Korzun WJ, Myers GL, Miller WG, Remaley AT. Evaluation of four different equations for calculating LDL-C with eight different direct HDL-C assays. Clin Chim Acta. 2013; 423:135-40.
Book Chapters and Monographs
Bachmann LM, Miller GW. Principles of spectrophotometry and related photometric measurements. In: Clarke W, Dufour RD, eds. Contemporary Practice in Clinical Chemistry. Fourth edition. Washington D.C.: AACC Press. 2020:119-133.
Cook JC, Bachmann LM, French D. Steroid Hormones. In: Nair H, Clarke W, eds. Mass Spectrometry for the Clinical Laboratory. First edition. Cambridge: Elsevier Inc., 2017:205-226.
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