J. Chuck Harrell, PhD
Associate Professor of Pathology
Phone: (804) 828-8710
Fax: (804) 828-9749
Chuck Harrell, PhD, Associate Professor, is a faculty member in the Department of Pathology since May 2015. Dr. Harrell earned his Bachelor of Science in Biological Sciences from North Carolina State University. While there, he worked at the National Institute of Environmental Health Sciences under the guidance of Dr. Kenneth Korach, and his research focus was aimed at discovering roles for estrogen receptors in human health. Dr. Harrell received his PhD degree in Cell and Developmental Biology from the University of Colorado, studying with Dr. Kathryn Horwitz. His PhD thesis focused on developing and testing models of estrogen receptor positive breast cancer metastasis. For post-doctoral training in genomics and bioinformatics, he joined the laboratory of Dr. Charles Perou at the University of North Carolina at Chapel Hill where he contrasted mechanisms of metastasis with all breast cancer subtypes using bioinformatic approaches.
Dr. Harrell’s research program focuses on identifying mechanisms to target to inhibit breast cancer metastatic growth in vital organs. His lab utilizes in vitro, in vivo, and in silico models to study each step of the metastatic cascade. Many projects incorporate patient-derived xenografts for proteogenomic analyses. Current projects are 1) utilizing patient-derived-xenograft models to identify genetic drivers of metastasis, 2) contrasting how individual patient genomic profiles correspond with targeted drug response at the single-cell level, 3) determining pharmacological approaches to overcome chemotherapeutic resistance, and 4) defining ancestral heritage contributions towards drug efficacy.
Dr. Harrell’s lab has been funded by the Department of Defense, Expedition Inspiration, the Jeffress Trust, National Cancer Institute, METAvivor, Susan G. Komen. His peer-reviewed publications primarily focus on breast cancer metastasis and the use of synergistic drug combinations to identify novel treatments.
Research interests: Cancer genomics, proteomics, metastasis, patient-derived breast cancer xenograft models, targeted therapeutics