Paula D Bos, PhD
Assistant Professor of Pathology
Office: (804) 828-7570
Paula D. Bos, PhD, joined the Department of Pathology as an Assistant Professor in October 2015. She is a member of the Cancer Cell Signaling and the Cancer Molecular Genetics programs at the Massey Cancer Center, and faculty of the Graduate School.
Dr. Bos received a M.S. in Genetics from the National University of Misiones, Argentina, working on molecular epidemiology of human papillomaviruses in caucassian and guarani populations of the Atlantic rainforest. She received a M.S. and Ph.D. in Cancer Biology from the Weill Cornell Graduate School of Medical Sciences working under the supervision of Dr. Joan Massagué. During her graduate work she developed breast cancer models of brain metastasis, and characterized molecular mediators of metastasis to the lung and brain. She did her post-doctoral training in the Immunology Program at the Memorial Sloan Kettering Cancer Center, under the supervision of Dr. Sasha Rudensky. During her post-graduate studies, she investigated the role of regulatory T cells in the progression and metastatic dissemination of murine oncogene-driven breast cancer.
Dr. Bos’ research program focuses on the characterization of regulatory T cell interactions with the tumor microenvironment that foster tumor progression and dissemination. Using genetic models that allow the manipulation of components of the environment, her team is trying to understand the reprogramming that takes place upon ablation of the Treg cell compartment, that leads to regression of tumors and disseminated disease. Understanding the specific contribution of Treg cells to cancer progression will open new therapeutic opportunities for the management of cancer.
During her training, Dr. Bos has received recognition from the National University of Misiones, National Senate of Argentina, and Rotary Club. She has received funding from the NIH, and the American Cancer Society, and served as the first Junior Investigator Chair of the Tumor Microenvironment Network of the National Cancer Institute. As an independent investigator at VCU, her lab received funding from the Massey Cancer Center and institutional research grant from the American Cancer Society. Currently, the lab is funded by the METAvivor foundation, the Susan G. Komen Foundation and the American Brain Tumor Association.
Research Interests: Tumor Microenvironment, Regulatory T cells, Breast Cancer Progression and Metastatic Dissemination.